| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275214 | Neuroscience | 2013 | 21 Pages |
Abstract
⺠Caspase inhibition and pre-incubation with BDNF abrogate excitotoxicity-induced chromatin condensation. ⺠Proteasome/calpains contribute to excitotoxicity-induced neurite damage. ⺠Proteasome/calpains do not contribute to excitotoxicity-induced chromatin condensation. ⺠Pre-incubation with BDNF protects neurites from excitotoxic damage. ⺠The protective effect of BDNF in neurites is mediated by phosphatidylinositol 3-kinase and phospholipase C-γ (PLCγ).
Keywords
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
C.V. Melo, S. Okumoto, J.R. Gomes, M.S. Baptista, B.A. Bahr, W.B. Frommer, C.B. Duarte,