| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275228 | Neuroscience | 2013 | 20 Pages |
Abstract
⺠Pharmacologically and genetically induced NMDAR hypofunction was assessed in rats and mice. ⺠MK-801 reduced both spontaneous and elicited hippocampal theta power. ⺠Grin1 mice showed similar neurophysiological abnormalities to MK-801-treated mice. ⺠AMPA-PAM improved both in pharmacological and genetic NMDA hypofunction models. ⺠Models proposed for glutamate-targeting drug candidate evaluation.
Keywords
NMDARalpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorLFPCA1PAMGRIN1AMPARMK-801npoMPFCSchizophreniaReceptor occupancyElectroencephalogramanalysis of varianceANOVAintraperitonealIntravenousdizocilpinesubcutaneouslynucleus pontis oralismedial prefrontal cortexpositive allosteric modulatorMouseRatEEGtheta oscillationlocal field potentialN-methyl-d-aspartate receptor
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Authors
T. Kiss, J. Feng, W.E. Hoffmann, C.L. Shaffer, M. Hajós,