| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275250 | Neuroscience | 2013 | 11 Pages |
Abstract
⺠BALB/cOLaHsd mice do not respond to chronic desipramine treatment in the NIH. ⺠Addition of lithium to desipramine induced antidepressant-like behaviour in the NIH. ⺠Lithium plus desipramine but neither drug alone increased hippocampal cell proliferation. ⺠Hippocampal neurogenesis may contribute to lithium augmentation of antidepressants.
Keywords
NIHSGZNGSGSK3GCLqRT-PCRLithiumBDNFTreatment-resistant depressionAugmentationBehaviourquantitative real time-PCRnormal goat serumAntidepressantVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Brain-derived neurotrophic factorgranule cell layersubgranular zoneHippocampal neurogenesisnovelty-induced hypophagiaglycogen synthase kinase 3
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Authors
O.F. O'Leary, S. Zandy, T.G. Dinan, J.F. Cryan,