| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275277 | Neuroscience | 2013 | 10 Pages |
Abstract
⺠Deficiency in 5-, but not 12/15-, lipoxygenase is associated with reduced striatal dopamine and tyrosine hydroxylase levels. ⺠5-Lipoxygenase deficiency protects against nigrostriatal damage from MPTP. ⺠Diminished inflammatory response is noted in null 5-lipoxygenase vs. wildtype mice after intoxication by MPTP.
Keywords
MPTPDOPACDABLTB4nigrostriatalPPARγGFAP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3,3′-diaminobenzidineROSEDTAEthylenediaminetetraacetic acidArachidonic acidhydroxyeicosatetraenoic acidinflammationLOXAlzheimer’s diseaseParkinson’s diseaseanalysis of varianceANOVAtyrosine hydroxylaseDopaminedihydroxyphenylacetic acidLeukotriene B4lipoxygenaselipoxygenase(s)wildtypeHETEhomovanillic acidglial acidic fibrillary proteinHVAReactive oxygen species
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Authors
V.P. Chou, T.R. Holman, A.B. Manning-Bog,