| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275312 | Neuroscience | 2012 | 12 Pages |
Abstract
⺠Lipopolysaccharide (LPS) activates microglial cells in a region, time and dose-dependent manner. ⺠LPS induced an increase of CB1 mRNA in the hippocampus and brainstem. ⺠LPS treatment reduced CB1 immunoreactivity in the CA3 pyramidal layer of the hippocampus. ⺠Reduced CB1 expression was largely restricted to glutamatergic terminals. ⺠Peripheral LPS treatment leads to limited changes in CB1 expression in the brain.
Keywords
MBHDMNPAGNTSCA3AMYGBNSTCVOsVGLUT1GAD65TNFα12nOVLTHIPPVMHMNPOPEV9-TetrahydrocannabinolVMpoTHCPVTMPACA1LPSBLABMASFOACODMHCECAcbIba-1SALAmygdalavascular organ of the lamina terminaliscircumventricular organssubstantia nigratumor necrosis factor αvesicular glutamate transporter 1periaqueductal graySalineMicroglial cellsdentate gyrusarea postremaSubfornical organSONArclipopolysaccharidePVNmedian eminencemedial preoptic areaNucleus accumbenshypoglossal nucleusSupraoptic nucleusanterior cortical amygdaloid nucleusParaventricular thalamic nucleusbed nucleus of the stria terminalisNucleus of solitary tractlateral septal nucleusdorsal motor nucleus of the vagusdorsomedial hypothalamic nucleusVentromedial hypothalamic nucleuslateral hypothalamic nucleusarcuate hypothalamic nucleusparaventricular hypothalamic nucleusperiventricular hypothalamic nucleusmedian preoptic nucleusmedial basal hypothalamusHippocampuspolymerase chain reactionPCRCannabinoidsCannabinoidglutamate decarboxylase 65
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Authors
H. Hu, W. Ho, K. Mackie, Q.J. Pittman, K.A. Sharkey,