| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275320 | Neuroscience | 2012 | 14 Pages |
Abstract
⺠Yokukansan (YKS) is a traditional Japanese herbal medicine clinically used for BPSD. ⺠Repeated administration of YKS inhibits morphine tolerance and physical dependence. ⺠The inhibition is due to prevention of decrease in α2A-AR by its prolonged blockade. ⺠YKS and its chemical constituents show antagonist activity against α2A-AR. ⺠The active constituents are responsible for the inhibitory effect of YKS.
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Neuroscience (General)
Authors
T. Nakagawa, K. Nagayasu, N. Nishitani, H. Shirakawa, K. Sekiguchi, Y. Ikarashi, Y. Kase, S. Kaneko,