Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis

► We discovered a novel interaction between the POZ/BTB protein NAC1 and TDP-43. ► We developed a spinal cord culture, glutamate toxicity model to mimic ALS. ► Glutamate treatment causes mis-localization, fragmentation and phosphorylation of TDP-43. ► Glutamate treatment induced increased co-localization of cytoplasmic TDP-43 and NAC1. ► The interaction of NAC1 and TDP-43 may link TDP-43 to the proteasome.