| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275338 | Neuroscience | 2012 | 12 Pages |
Abstract
⺠Diabetes-induced synaptic changes depended on the onset of diabetes. ⺠Young adult-onset STZ-rats showed impaired LTP and the alteration of AMPA/NMDA ratio. ⺠Juvenile-onset STZ-rats showed impaired LTD and enhanced EPSCs. ⺠An NMDA receptor antagonist restored LTD in juvenile-onset STZ-rats.
Keywords
VMRSTZAPVN-methyl-d-aspartateNMDAHFSD-2-amino-5-phosphonopentanoic acidaCSFLFSHippocampal synaptic plasticityTBSEGTACA1PPFHEPESField EPSPs4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidfEPSPsethylene glycol tetraacetic acidStreptozotocinelong-term depressionDiabeteslow-frequency stimulationhigh-frequency stimulationanalysis of varianceANOVATris–buffered salinepaired-pulse facilitationlong-term potentiationLTPDiabetes mellitusCNQXartificial cerebrospinal fluidLTDresting membrane potentialNMDA receptorsAMPA receptors
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Authors
S. Sasaki-Hamada, H. Sacai, J.-I. Oka,