Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6275366 | Neuroscience | 2012 | 9 Pages |
Abstract
⺠We tested the combination treatment of stroke with a low dose of Simvastatin and HUCBC. ⺠Combination treatment increases Ang1/Tie2/Occludin expression in the ischemic brain. ⺠Combination treatment amplifies angiogenesis/arteriogenesis/vascular remodeling. ⺠The increased angiogenesis/arteriogenesis is correlated to functional outcome. ⺠The therapeutic effects support exploration of using HUCBCs in stroke treatment.
Keywords
PBSmNSSischemic boundary zoneIBZ5-bromodeoxyuridineMCAOEPCsCCAvWFMCIDangiopoietin-1SMCsαSMAMBECAng1ECsalpha smooth muscle actinmiddle cerebral artery occlusionVascular remodelingBrdUHuman umbilical cord blood cellsSmooth muscle cellsEndothelial progenitor cellsEndothelial cellsStrokeSimvastatincommon carotid arteriesVon Willebrand factorphosphate-buffered solution
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Neuroscience (General)
Authors
X. Cui, M. Chopp, A. Zacharek, J. Dai, C. Zhang, T. Yan, R. Ning, C. Roberts, A. Shehadah, N. Kuzmin-Nichols, C.D. Sanberg, J. Chen,