Anterior thalamic nuclei lesions in rats disrupt markers of neural plasticity in distal limbic brain regions

Article ID	Journal	Published Year	Pages	File Type
6275384	Neuroscience	2012	21 Pages	PDF

Abstract

âº Anterior thalamic lesions alter the ratio of hippocampal CREB to pCREB. âº Anterior thalamic lesions reduced pCREB in granular retrosplenial cortex. âº Changes in limbic pCREB may explain learning deficits after anterior thalamic lesions. âº zif268 Hypoactivity in granular retrosplenial cortex after anterior thalamic lesions. âº Hippocampal zif268 levels relatively insensitive to anterior thalamic damage.

Keywords

Postsubiculum N-methyl-d-aspartic acid GAP-43 IDG IEG ATN pCREB CREB zif268 PRH NMDA PFA PBST TCA HPC PBS DAB BSA bovine serum albumin diaminobenzidine phosphorylated CREB phosphate buffer saline infralimbic cortex medial entorhinal cortex Retrosplenial cortex primary auditory cortex lateral entorhinal cortex perirhinal cortex prelimbic cortex dorsal subiculum Ment Hippocampus immediate early gene