Inhibition of endoplasmic reticulum Ca2+ ATPase in preBötzinger complex of neonatal rat does not affect respiratory rhythm generation

Article ID	Journal	Published Year	Pages	File Type
6275385	Neuroscience	2012	9 Pages	PDF

Abstract

âº We examined the effect of blocking SERCA on respiratory rhythm generation in an in vitro preparation. âº Thapsigargin and CPA do not affect period or amplitude of respiratory-related motor output. âº SERCA blockade and depletion of Ca2+ stores do not affect the mechanisms for rhythm generation. âº We suggest that Ca2+ from intracellular stores does not play a relevant role for rhythm generation.

Keywords

CPA ICAN InsP3R PreBötzinger complex VGCC Thapsigargin aCSF APs Cyclopiazonic acid Ca2+-induced Ca2+ release respiratory rhythm generation endoplasmic reticulum SERCA artificial cerebrospinal fluid Breathing action potentials preBötC voltage-gated Ca2+ channels CICR Inositol 1,4,5-trisphosphate receptor