The role of basolateral amygdala in the regulation of stress-induced phosphorylated extracellular signal-regulated kinase expression in the hippocampus

Article ID	Journal	Published Year	Pages	File Type
6275391	Neuroscience	2012	11 Pages	PDF

Abstract

âº Effect of amygdala lesion on the stress-induced GR translocation in the hippocampus. âº Effect of amygdala lesion on the stress-induced alteration of pERK in the hippocampus. âº Amygdala lesions selectively blocked the stress-induced alterations of pERK. âº Stress-induced hippocampal GR translocation occurred in rats with amygdala lesions. âº Amygdala modulates stress-induced cognitive impairments regulating the ERK signaling.

Keywords

BLA NMDA N-methyl-d-aspartate ADX PBST TBST IgG PBS mitogen-activating protein kinase tris-buffered saline containing tween-20 DEX SDS basolateral amygdala NER MAPK adrenalectomy Amygdala Posttraumatic stress disorder PTSD Stress immunoglobulin G phosphate buffer analysis of variance ANOVA long-term potentiation LTP Room temperature Dexamethasone sodium dodecylsulfate Cer dentate gyrus ERK phosphorylation MEK Phosphate-buffered saline Hippocampus PERK Glucocorticoids glucocorticoid receptor