The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy

Article ID	Journal	Published Year	Pages	File Type
6275403	Neuroscience	2012	12 Pages	PDF

Abstract

âº FBG1 promotes torsinA degradation. âº FBG1 acts through both the proteasome and autophagy. âº The N-terminal domain of FBG1 is key for its functional versatility. âº Absence of FBG1 triggers age-related motor dysfunction in torsinA(ÎE) knock-in mice.

Keywords

ERAD NGF 3-MA SCF 3-methyladenine H&E Alkaline phosphatase endoplasmic reticulum-associated degradation CASA knock in endoplasmic reticulum nerve growth factor knock out Hematoxylin and Eosin