Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer's Disease patients

Article ID	Journal	Published Year	Pages	File Type
6275434	Neuroscience	2012	6 Pages	PDF

Abstract

âº Decrease in SNAP25 expression in brain areas of Alzheimer's Disease in relation to elderly controls. âº SNAP25 mRNA expression alterations in brain might suggest an impairment in synaptic function. âº The changes in the auditory cortex reflected those in the hippocampus and the entorhinal cortex. âº No Alzheimer's Disease-associated differences in SNAP25 promoter DNA methylation.

Keywords

PSEN1 MMSE βA SNAP25 APP DSM-IV Number of individuals qRT-PCR PSEN2 GLM Promoter DNA methylation CDR MALDI-TOF presenilin 1 β-Amyloid cycle threshold Apoe apolipoprotein E Clinical Dementia Rating standard deviation Relative quantification Alzheimer’s disease base pair degrees of freedom PCR–RFLP Female Aging Matrix-assisted Laser Desorption Ionization Time of Flight mass spectrometry GLM, General Linear Model Mini-Mental State Examination Male quantitative reverse transcription polymerase chain reaction amyloid precursor protein Presenilin 2 polymerase chain reaction–restriction fragment length polymorphism