| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275435 | Neuroscience | 2012 | 15 Pages |
Abstract
⺠A novel hypoglycosylated protein in POMGnT1 knockout brains, a model of CMDs. ⺠RPTPζ/phosphacan is a likely substrate for O-mannosylation by POMGnT1 in vivo. ⺠HNK-1 glycans on RPTPζ/phosphacan are diminished in POMGnT1 knockouts. ⺠Glycosylation of RPTPζ/phosphacan is unaffected in LARGE knockouts.
Keywords
ECMα-DGCMDs+/−HNK-1ChABCPOMGNT1α-dystroglycanethylenediamminetetraacetate+/+−/−MEBEDTACNScongenital muscular dystrophiesembryonic daypostnatal daySubplatecentral nervous systemperineuronal netscortical platemuscle–eye–brain diseasephosphacanExtracellular matrixmarginal zoneintermediate zoneknockoutwildtypeheterozygousPNSchondroitinase ABCProtein glycosylation
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Authors
C.A. Dwyer, E. Baker, H. Hu, R.T. Matthews,