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Developmental alterations in CNS stress-related gene expression following postnatal immune activation

Article ID Journal Published Year Pages File Type
6275440 Neuroscience 2012 10 Pages PDF
Abstract
► Early immune challenge in mice alters CNS stress-related gene expression. ► Altered gene expression occurs during a critical developmental time window. ► Early changes to stress-related gene expression may underlie adult behavioral dysfunction.
Keywords
5-HTPOMCCA35-HT2C5-HT2Apro-opiomelanocortinSSCdpmBLACPMmRNACA1CRHserotonin receptor 2ACrhr1LPSSerotonin receptor 2CCRHR2PBSACTHbasolateral amygdalaCeASALCentral amygdalagamma-aminobutyric acidinterleukindisintegrations per minuteneurodevelopmenttumor necrosis factor-αstandard error of the meanCNSmessenger ribonucleic acidSalinesaline-sodium citrateSerotonincentral nervous systemcounts per minutedentate gyrusTNF-αPhosphate buffered salinelipopolysaccharidePVNHPA axisSEMHPAparaventricular nucleuscorticotropin-releasing hormonehypothalamic–pituitary–adrenalPostnatalImmune challengeCORTCorticosteroneGABAMineralocorticoid receptorglucocorticoid receptor
Related Topics
Life Sciences Neuroscience Neuroscience (General)
Preview
Developmental alterations in CNS stress-related gene expression following postnatal immune activation
Authors
A. Amath, J.A. Foster, M.M. Sidor,
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Journal
Neuroscience
Journal: Neuroscience
Related Categories
5-HT
POMC
CA3
5-HT2C
5-HT2A
pro-opiomelanocortin
SSC
dpm
BLA
CPM
mRNA
CA1
CRH
serotonin receptor 2A
Crhr1
LPS
Serotonin receptor 2C
CRHR2
PBS
ACTH
basolateral amygdala
CeA
SAL
Central amygdala
gamma-aminobutyric acid
interleukin
disintegrations per minute
neurodevelopment
tumor necrosis factor-α
standard error of the mean
CNS
messenger ribonucleic acid
Saline
saline-sodium citrate
Serotonin
central nervous system
counts per minute
dentate gyrus
TNF-α
Phosphate buffered saline
lipopolysaccharide
PVN
HPA axis
SEM
HPA
paraventricular nucleus
corticotropin-releasing hormone
hypothalamic–pituitary–adrenal
Postnatal
Immune challenge
CORT
Corticosterone
GABA
Mineralocorticoid receptor
glucocorticoid receptor
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Developmental Neuroscience
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