Increased inflammation and brain injury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice

Article ID	Journal	Published Year	Pages	File Type
6275441	Neuroscience	2012	9 Pages	PDF

Abstract

âº ATF3 deletion significantly exacerbated ischemic cerebral injury. âº ATF3 deletion led to a remarkable aggravation of post-ischemic inflammatory response. âº The activity of NF-ÎºB signaling pathway was upregulated in the ischemic brain of ATF3 knockout mice.

Keywords

NF-κB 2,3,5-triphenyl-2H-tetrazolium chloride TNF VCAM ICAM MMP9 TMCAO HDAC1 ATF3 TLR AP-1 CBF CREB MCA TTC MCP inflammation transient middle cerebral artery occlusion Cerebral ischemia interleukin Toll-like receptor cerebral blood flow middle cerebral artery tumor necrosis factor Nuclear factor-kappa B activating transcription factor intercellular adhesion molecule vascular cell adhesion molecule knockout wild-type histone deacetylase 1 monocyte chemoattractant protein activator protein 1 cAMP-responsive element-binding protein