| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275464 | Neuroscience | 2012 | 12 Pages |
Abstract
⺠The perifornical-lateral hypothalamic area (PF-LHA) is a wake-promoting region. ⺠Nitric oxide (NO), a sleep-promoting factor, inhibits majority of PF-LHA neurons. ⺠Blockade of sGC-cGMP signaling attenuated NO-evoked suppression of PF-LHA neurons. ⺠Blockade of GABAA as well as adenosine A1 receptors also attenuated NO-evoked actions. ⺠Adenosinergic, GABAergic and sGC-cGMP mechanisms contribute to the actions of NO on PF-LHA neurons.
Keywords
CPTSGCHcrtMCHnNOSaCSFiNOSNOSBICcGMPNonREMODQAdenosinegamma-aminobutyric acidElectroencephalogramNon-rapid eye movement sleepSleepinducible nitric oxide synthaseneuronal nitric oxide synthaseartificial cerebrospinal fluidSleep deprivationcyclic guanosine monophosphateEEGNitric oxidenitric oxide synthasemelanin-concentrating hormonebasal forebrainNOC-18GABAguanylyl cyclase
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Authors
A. Kostin, D. McGinty, R. Szymusiak, M.N. Alam,