Article ID Journal Published Year Pages File Type
6275499 Neuroscience 2012 14 Pages PDF
Abstract
► The role of MMPs in neuronal apoptosis was investigated in vivo and in vitro. ► In an animal model of stroke, a broad-spectrum MMP inhibitor was neuroprotective. ► In primary neurons, MMP-2 and -9 activities increased in the nucleus after OGD. ► Inhibition of MMP-2 and -9 prevented DNA damage and apoptosis in ischemic neurons. ► The results suggest a major role for intranuclear MMPs in neuronal apoptosis.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
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