ATP excites mouse vomeronasal sensory neurons through activation of P2X receptors

Article ID	Journal	Published Year	Pages	File Type
6275517	Neuroscience	2012	10 Pages	PDF

Abstract

âº Purinergic signaling is an important component of the chemical senses. âº ATP increased intracellular calcium in VSNs through P2X receptors. âº ATP elicited an inward current and action potentials in VSNs through P2X receptors. âº The chemosensory response of VSNs was increased by ATP. âº Mechanical stimulation of the VNO induced ATP release.

Keywords

PPADS perforated patch clamp VSN TNP-ATP Trpc2 cyclic adenosine 5′-monophosphate VDCC UDP ConA RLU VNO UTP PLC RT-PCR IP3 ADP cACC cAMP inositol-1,4,5-trisphosphate uridine 5′-triphosphate adenosine 5′-triphosphate ATP adenylyl cyclase vomeronasal organ Main olfactory epithelium excitability analysis of variance ANOVA diacylglycerol DAG OSN olfactory sensory neuron Pheromones phospholipase C relative light unit reverse transcription polymerase chain reaction MOE voltage dependent calcium channel Calcium-activated chloride channel Purinergic receptors