| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275524 | Neuroscience | 2012 | 14 Pages |
Abstract
⺠Microglia have plastic expression of SR-A upon cerebral ischemia. ⺠SR-A contributes to the cerebral ischemic injury. ⺠Cerebral ischemic injury mediated by SR-A is NF-κB pathway-dependent. ⺠SR-A could control the microglia activation associated with brain ischemia. ⺠SR-A promotes ischemia-induced pro-inflammatory M1 microglia polarization.
Keywords
NF-κBCBFMCP-1MCAOiNOSTTCIFN-γRIPAHRPAβClass A scavenger receptorFBSSR-ALPSPBSPDTCMacrophage chemoattractant protein-1EDTAEthylenediaminetetraacetic acidinflammationIschemiainterferon-γinterleukinamyloid betatumor necrosis factor-αcerebral blood flowfetal bovine seruminducible nitric oxide synthaseradioimmunoprecipitation assayStrokeTNF-αnuclear factor-kappaBlipopolysaccharideMacrophagePhosphate-buffered salineMicrogliapolymerase chain reactionPCR
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Authors
Y. Xu, Lingling Qian, Guijuan Zong, K. Ma, X. Zhu, H. Zhang, N. Li, Q. Yang, H. Bai, J. Ben, X. Li, Y. Xu, Q. Chen,