Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice

Article ID	Journal	Published Year	Pages	File Type
6275527	Neuroscience	2012	9 Pages	PDF

Abstract

âº Neonatal DEX-treated females show delayed pubertal onset and altered estrus cycle. âº Neonatal DEX treatment inhibits GnRH mRNA expression in the POA. âº Neonatal DEX treatment increases GnIH receptors mRNA levels in the POA. âº Neonatal DEX treatment increases immunostained GnIH cell numbers in the DMH. âº GnIH through its receptors inhibits preoptic GnRH causing delayed pubertal onset.

Keywords

DMH 3,3′diaminobenzidine tetrahydrochloride GnRH GPR147 HPG DEPC PFA DTM GnIH GFAP CyP RPM POA GPR IgG DEX DAB PBS G-protein coupled receptors Stress immunoglobulin G phosphate buffer analysis of variance ANOVA Reproduction Dexamethasone diethylpyrocarbonate revolutions per minute cyclophilin Phosphate buffered saline Preoptic area HPA Gonadotropin-releasing hormone luteinizing hormone Gonadotropin-inhibitory hormone dorsomedial hypothalamus paraformaldehyde Glial fibrillary acidic protein Postnatal Glucocorticoid glucocorticoid receptor