| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275566 | Neuroscience | 2012 | 14 Pages |
Abstract
⺠A novel bilateral rat model of Parkinson's disease resulted in loss of approximately 80% striatal DA. ⺠Chronic L-DOPA-induced time-dependent imbalances in DA/5-HT levels in extrastriatal brain areas. ⺠Prior exposure to L-DOPA did not damage DA and 5-HT neurons. ⺠Anxiogenic effects of chronic L-DOPA were observed in bilateral-lesioned rats during the OFF phase.
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Authors
K.L. Eskow Jaunarajs, J.A. George, C. Bishop,