Nitric oxide signaling modulates cholinergic synaptic input to projection neurons in Drosophila antennal lobes

Article ID	Journal	Published Year	Pages	File Type
6275594	Neuroscience	2012	9 Pages	PDF

Abstract

âº NO inhibits cholinergic synaptic input to PNs. âº Inhibition of sGC by ODQ enhances cholinergic synaptic input to PNs. âº cGMP attenuated the effects of ODQ on cholinergic synaptic input to PNs. âº NO decreases quantal release of acetylcholine in a sGC-dependent manner.

Keywords

NADPH nAChR NADPHd NOS IPSPs cGMP mEPSCs sEPSCs EGTA MBS HEPES EPSPs SGC LNs ODQ OSNs cGMP-dependent protein kinases 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid BSA DMSO bovine serum albumin ACh ethylene glycol tetraacetic acid Acetylcholine Mushroom bodies ALS spontaneous excitatory postsynaptic currents miniature excitatory postsynaptic currents Soluble guanylyl cyclase CNS NADPH diaphorase Dimethyl sulfoxide Nitric oxide synthases central nervous system Cholinergic synapse SNAP Olfactory sensory neurons Antennal lobes cyclic guanosine monophosphate Drosophila projection neuron Projection neurons sodium nitroprusside Nitric oxide nicotinamide adenine dinucleotide phosphate excitatory postsynaptic potentials inhibitory postsynaptic potentials SNP PNS nicotinic acetylcholine receptor