| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275598 | Neuroscience | 2012 | 15 Pages |
Abstract
⺠Inhibition of mTOR by rapamycin increases seizure susceptibility to pilocarpine in immature rats, but not in mature rats. ⺠Rapamycin down-regulates KCC2 expression in the thalamus and hippocampus. ⺠Inhibition of thalamic mTOR and KCC2 increases seizure susceptibility to pilocarpine.
Keywords
VA/VLKCC2ROImTORPTZN-methyl-d-aspartateTSCSNRNMDAEDTAEthylenediaminetetraacetic acidElectroencephalographystatus epilepticusEpilepsyanalysis of varianceANOVAseizuresubstantia nigraRoom temperatureRapamycinDevelopmentphosphatase and tensin homologRegions Of InterestEEGmammalian target of rapamycinpentylenetetrazolPtenTuberous sclerosis complexGlobus pallidus
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Authors
X. Huang, J. McMahon, J. Yang, D. Shin, Y. Huang,