Nicotine improves ethanol-induced impairment of memory: Possible involvement of nitric oxide in the dorsal hippocampus of mice

► Pre-test injection of nicotine reversed the amnesia induced by ethanol. ► Pre-test injection of nicotine plus ethanol reversed ethanol-induced amnesia. ► Ethanol amnesia was also prevented by pre-test intra-CA1 injection of l-arginine. ► Ineffective dose of nicotine potentiate l-arginine effect on ethanol amnesia. ► Injection of L-NAME prevented improving effect of nicotine on ethanol amnesia.