| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275628 | Neuroscience | 2012 | 8 Pages |
Abstract
⺠We explore GSH and S-nitrosothiols (RSNO) levels during acute phase of EAE. ⺠EAE animals were treated by aminoguanidine and N-acetyl-L-cysteine. ⺠The GSH levels are decreased and RSNO levels are increased during early phase of EAE. ⺠Increased GSH level and thiols content in CNS ameliorate clinical signs of EAE. ⺠GSH and RSNO appear to be the potential biomarkers and therapeutic targets in EAE.
Keywords
NADPHEAERNSEAAT1iNOSGSSGGSHGSNOGFAPS-nitrosoglutathioneS-nitrosothiolsLWMPBSWEMCFARSNOcomplete Freund’s adjuvantROSAminoguanidineexperimental autoimmune encephalomyelitistumor necrosis factor-αexcitatory amino acid transporterinducible nitric oxide synthaseTNF-αPhosphate buffered salineMultiple sclerosisNitric oxidenicotinamide adenine dinucleotide phosphate (reduced form)Glial fibrillary acidic proteinGlutathioneglutathione disulfidereactive nitrogen speciesReactive oxygen species
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Authors
S. Ljubisavljevic, I. Stojanovic, R. Pavlovic, S. Stojnev, I. Stevanovic, D. Sokolovic, D. Pavlovic,