| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275646 | Neuroscience | 2012 | 12 Pages |
Abstract
⺠5-HT1A receptor agonist DPAT produces pronociceptive effects in visceral pain. ⺠DPAT activates of presynaptic 5-HT1A receptors to inhibit GABA release. ⺠Inhibition of GABAergic neurons unmasks the excitatory glutamatergic system. ⺠This effect results in visceral hyperalgesia in behavioral studies. ⺠The electrophysiology experiments also confirm the findings of behavioral studies.
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Authors
A. Mickle, P. Kannampalli, M. Bruckert, A. Miranda, B. Banerjee, J.N. Sengupta,