Overexpression of cellular prion protein (PrPC) prevents cognitive dysfunction and apoptotic neuronal cell death induced by amyloid-Î² (AÎ²1-40) administration in mice

Article ID	Journal	Published Year	Pages	File Type
6275671	Neuroscience	2012	11 Pages	PDF

Abstract

âº Overexpression of PrPC prevents AÎ²1-40-induced spatial learning and memory deficits. âº Overexpression of PrPC prevents AÎ²1-40-induced hippocampal cell damage. âº PrPC inhibits programed cell death mechanisms activated by AÎ²1-40 peptide in vivo.

Keywords

Aβ i.c.v.intracerebroventricular KRb Cellular prion protein (PrPC)PrPc 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Ca2+DMSO MTT amyloid-β Krebs–Ringer bicarbonate buffer Alzheimer’s disease analysis of variance ANOVA long-term potentiation LTP south Apoptosis Dimethyl sulfoxide EAST North West polymerase chain reaction PCR Potassium inhibitory postsynaptic potentials amyloid-β protein Propidium iodide cellular prion protein Caspase-3 Calcium Learning and memory