| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275689 | Neuroscience | 2012 | 14 Pages |
Abstract
⺠Olfactory functional deficits are common in aged humans and AD patients. ⺠Olfactory nerve dystrophy was identified in 5XFAD mice and aged/AD humans. ⺠Dystrophic olfactory nerve terminals over-expressed amyloidogenic proteins. ⺠Axonal degeneration but not local Aβ deposition occurred around the glomeruli. ⺠The olfactory nerve terminal pathology may relate to olfactory dysfunction.
Keywords
PBSSEZNFLMAP2VGLUT2OMPGap43EPLGCLAPPAβAxonal pathologyAmyloidogenesisFADAlzheimer’s diseasetyrosine hydroxylaseDementiaAgingFamilial ADexternal plexiform layergranule cell layerNerve fiber layerglomerular layerPhosphate-buffered salineSubependymal zoneolfactory marker proteingrowth-associated protein 43microtubule-associated protein-2β-amyloid precursor proteinβ-amyloid peptide
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Authors
Y. Cai, Z.-Q. Xue, X.-M. Zhang, M.-B. Li, H. Wang, X.-G. Luo, H. Cai, X.-X. Yan,