Morphine and MK-801 administration leads to alternative N-methyl-d-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay

Article ID	Journal	Published Year	Pages	File Type
6275704	Neuroscience	2012	14 Pages	PDF

Abstract

âº Morphine tolerance and withdrawal induces altered NMDA receptor splicing. âº NMDA receptor antagonism potentiates motivational reward seeking behavior. âº MK-801 potentiates morphine-induced NMDAR splicing in the accumbens.

Keywords

VPM HIPP accumbens NMDA NR1 PAG NMDAR VTA NAcc Amygdala AMY repeated measures periaqueductal gray Pain GAP Spinal cord locus coeruleus morphine ventral tegmental area Nucleus accumbens Hippocampus dorsal hippocampus non-significant glyceraldehyde 3-phosphate dehydrogenase N-methyl-d-aspartate receptor