Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains

Article ID	Journal	Published Year	Pages	File Type
6275709	Neuroscience	2012	9 Pages	PDF

Abstract

âº Central BDNF administration produced ameliorative effect on depressive-like behavior. âº Long-term BDNF effect on “depressive” ASC mice involves profound genetic mechanisms. âº In ASC mice BDNF increased Tph2, Htr1A and Htr2A genes expression. âº In ASC mice BDNF produced sensitization of Htr2A receptor.

Keywords

5-HT ASC TST DOI 5-HTT 8-OH-DPAT Tph-2 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 8-hydroxy-2-(di-n-propylamino)tetralin BDNF Tail suspension test tryptophan hydroxylase-2 Depressive-like behavior Serotonin Brain-derived neurotrophic factor selective serotonin reuptake inhibitors Catalepsy