| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275711 | Neuroscience | 2012 | 10 Pages |
Abstract
⺠We studied the effect of HIV-1 gp120 on different caspases (3, 6, 8, 9) expression. ⺠Gp120 was injected into the rat caudate-putamen. ⺠Caspases expression peaked by 24 h and they colocalized mainly with neurons. ⺠We then delivered antioxidant enzymes SOD1or GPx1 into the CP before injecting gp120. ⺠Antioxidant enzymes delivery reduced production of caspases, by reducing ROS levels.
Keywords
HAARTHIV-1-associated dementiaHIV-1 associated neurocognitive disordersGPx1HNEIBA1APAf-1DAPIiNOSFITCGFAP4′,6-diamidino-2-phenylindolecaudate-putamenHydrogen peroxideamyotrophic lateral sclerosisAIDSlateral ventricleAlzheimer’s diseaseALSHADHandCNSinducible nitric oxide synthaseacquired immune deficiency syndromecentral nervous systemapoptotic protease activating factor 1fluorescein isothiocyanateionized calcium binding adaptor molecule 1H2O2hydroxynonenalHIV-1Human immunodeficiency virus type 1Glial fibrillary acidic proteinglutathione peroxidase
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Authors
J.-P. Louboutin, L. Agrawal, B.A.S. Reyes, E.J. van Bockstaele, D.S. Strayer,