| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275712 | Neuroscience | 2012 | 6 Pages |
Abstract
⺠Infusion of substance P (SP) after traumatic brain injury (TBI) promotes cellular proliferation. ⺠SP-induced cell proliferation after TBI was largely associated with microglial proliferation. ⺠Inhibition of SP activity after TBI with NK1 antagonists improves motor outcome. ⺠NK1 antagonists reduce microglial proliferation after TBI. ⺠Substance P-induced microglial proliferation after TBI is deleterious to functional outcome.
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Authors
H.L. Carthew, J.M. Ziebell, R. Vink,