Substance P release in response to cardiac ischemia from rat thoracic spinal dorsal horn is mediated by TRPV1

Article ID	Journal	Published Year	Pages	File Type
6275715	Neuroscience	2012	14 Pages	PDF

Abstract

âº A TRPV1 mechanism mediates cardiac ischemia-induced SP release in the spinal cord. âº TRPV1 mediates spinal neuronal activation as indexed by c-Fos expression. âº TRPV1 is possibly linked to spinal cord stimulation therapy for angina.

Keywords

PBS STT CZP DRG AEA anandamide membrane transporter N-arachidonoylethanolamide AMT SCs BSA bovine serum albumin coronary artery occlusion bpm Spinal cord stimulation Spinothalamic tract beats per minute Heart rate Phosphate buffered saline mean arterial pressure LAD Substance P map Nitric oxide arbitrary units left anterior descending coronary artery CaP Capsaicin capsazepine dorsal root ganglia