| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275733 | Neuroscience | 2012 | 11 Pages |
Abstract
â¶We have studied synaptic plasticity of the cortico-subthalamic pathway. â¶We find HFS depresses cortico-subthalamic synapses but only in dopamine-depleted tissue. â¶LFS enhances transmission but only in dopamine-intact tissue. â¶Both these plasticity have presynaptic components. â¶Suggests dopamine-dependent changes in the synaptic weight of this pathway. â¶Suggests DBS promotes synaptic depression in Parkinson's disease.
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Authors
N. Yamawaki, P.J. Magill, G.L. Woodhall, S.D. Hall, I.M. Stanford,