| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275772 | Neuroscience | 2012 | 13 Pages |
Abstract
Oxaliplatin evokes a chronic painful peripheral sensory neuropathy in rat. â¶Oxaliplatin induces abnormal spontaneous discharge in A-fibers and C-fibers. â¶Oxaliplatin induces swelling and vacuolation in axonal mitochondria. â¶IENF degeneration is present without degeneration of peripheral nerve axons. â¶Oxaliplatin-induced effects are very similar to those induced by paclitaxel.
Keywords
TRPV1SNCVIENFmitotoxicitychemotherapy neuropathyTransient receptor potential ankyrin 1 channelMNCVPGP9.5ALCARNAGVFHCMAPTRPM8TRPA1CIPNDRGATF-3dorsal root ganglionN-acetyl-β-d-glucosaminidaseVon Frey hairacetyl-l-carnitineBUNSensory nerve conduction velocitymotor nerve conduction velocitychemotherapy-induced peripheral neuropathyactivating transcription factor 3Intraepidermal nerve fiberElectron microscopySensory neuropathyblood urea nitrogencompound muscle action potentialprotein gene-product 9.5Carnitine
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Authors
W.H. Xiao, H. Zheng, G.J. Bennett,