Article ID Journal Published Year Pages File Type
6275773 Neuroscience 2012 9 Pages PDF
Abstract
▶5HT's role in peripheral TRPV1-evoked thermal hyperalgesia in the rat hind paw. ▶Examined changes in thermal sensitivity following peripheral serotonergic treatment. ▶5HT pretreatment enhances TRPV1-evoked thermal hyperalgesia in male and female rats. ▶Attenuated with peripheral pretreatment with ketanserin, graniestron, and sumatriptan. ▶In vivo evidence supporting reported enhancing role of 5HT on TRPV1 function in vitro.
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