| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275809 | Neuroscience | 2012 | 11 Pages |
Abstract
â¶Activation of mGluR7 with AMN082 attenuated sevoflurane-induced neuronal apoptosis. â¶AMN082 prevented sevoflurane neurotoxicity by modulating caspase-3, Bcl-2, and Bax. â¶Sevoflurane exposure inhibited phospho-ERK1/2 that could be restored by AMN082. â¶MEK inhibitor U0126 abolished the neuronal protective effects of AMN082. â¶AMN082 improved the cognitive defects induced by postnatal sevoflurane exposure.
Keywords
FCMSP600125AMN082U0126cJun N-terminal kinasemGluRsmGluRMWMl-AP4MSOPTerminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling(RS)-α-Methylserine-O-phosphate1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadieneHEPESJnkSevoflurane4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidERK1/2l-(+)-2-amino-4-phosphonobutyric acidMAPKMTTEDTAEthylenediaminetetraacetic acidTUNELNeurotoxicityFlow cytometryMorris water mazeHippocampusmitogen-activated protein kinaseextracellular signal-regulated kinase 1 and 2Metabotropic glutamate receptorLearning and memory
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Authors
W.-Y. Wang, H. Wang, Y. Luo, L.-J. Jia, J.-N. Zhao, H.-H. Zhang, Z.-W. Ma, Q.-S. Xue, B.-W. Yu,