Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6275885 | Neuroscience | 2012 | 8 Pages |
Abstract
â¶Immunohistochemical distribution of optineurin in the mouse striatum was studied. â¶Optineurin was abundantly expressed in the striatal interneurons. â¶By contrast, low levels of optineurin were found in the striatal projection neurons. â¶Thus, a cell type-specific localization of optineurin was found in the striatum. â¶Our findings are important in considering striatal pathology of Huntington's disease.
Keywords
NPYOptineurinMSNsinterneuronsDARPP-32httOPTNTSAPBSStriatumsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEphosphate bufferHuntington's diseaseTyramide Signal AmplificationNeurodegenerationPhosphate-buffered salinemedium spiny neuronsHuntingtinParvalbuminChATCalretinincholine acetyltransferaseNeuropeptide Y
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Authors
S. Okita, R. Morigaki, H. Koizumi, R. Kaji, S. Nagahiro, S. Goto,