Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

▶Hypercholesterolemia is associated with spatial learning and memory impairments. ▶Cortico-cerebral mitochondrial dysfunction is negatively correlated with hypercholesterolemia in LDLr−/− mice. ▶The glutathione antioxidant system is impaired in cerebral cortex of hyperclolesterolemic mice.