| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275990 | Neuroscience | 2011 | 10 Pages |
Abstract
â¶Orexin/hypocretin inputs to the medial septum and hippocampus modulate behavioral arousal and performance on hippocampal-dependent cognitive tasks. â¶Aging is associated with reduced orexin/hypocretin innervation of medial septum and hippocampus. â¶Aged rats showed alterations in orexin/hypocretin modulation of hippocampal glutamate and GABA efflux. â¶Changes in orexin/hypocretin signaling may contribute to age-related impairments in arousal and memory consolidation.
Keywords
SLMOX2RCA1stratum oriensaCSFOXAGad67REMglutamic acid decarboxylase 67OX1Rstratum radiatumcornu Ammonis 1stratum pyramidaleorexin AOrexinanalysis of varianceANOVAlong-term potentiationLTPrapid eye movementRoom temperatureAgingmedial septumstratum lacunosum moleculareartificial cerebrospinal fluidmicrodialysisHippocampusHypocretinParvalbuminOrexin 1 receptorOrexin 2 receptor
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Authors
E.M. Stanley, J.R. Fadel,