Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain

Article ID	Journal	Published Year	Pages	File Type
6276031	Neuroscience	2011	20 Pages	PDF

Abstract

â¶We described DAGLÎ± mRNA and protein distribution in rat forebrain. â¶We highlighted olfactory system, rostral migratory stream, neocortex, septum, thalamus and hypothalamus. â¶DAGLÎ± distribution, compared to that of CB1, MAGL and FAAH, is consistent with multiple roles for endocannabinoids in synaptic plasticity. â¶This description provides some insight into the potential physiological and behavioral roles of the endocannabinoid system.

Keywords

Corpus callosum PVA PBS MGM PVP CPU LSD STA AOP ECT LSI PPT LSV ACA BLA TBS AOM LGP SNC RMS ACO NBT OPT 2-AG Den magl aHI ADP BLP ACBC GCL PAG BST HDB VTA APir EPL IPL PRL FAAH amygdalopiriform transition area lateral globus pallidus SVZ LHb AcbSh BSTLV BCIP 5-bromo-4-chloro-3-indolyl phosphate BSTMA PMCo PVH 2-arachidonoyl-glycerol DLG MNPO MGV PRH BSTld MGD anterior commissure, anterior part SFI MGP AoV VLG stratum oriens VDB PIL ARCL ICJ Indusium griseum Posterior intralaminar thalamic nucleus M1/M2 basolateral amygdaloid nucleus, posterior part CxA ectorhinal cortex internal plexiform layer of the olfactory bulb LaDL LaVL LDvl lateral septal nucleus, intermediate part lateral septal nucleus, ventral part medial terminal nucleus of the accessory optic tract septofimbrial nucleus stria medullaris of the thalamus TuDC V2L VTT BSA Habenula In situ hybridization MHb Ventral pallidum SOR stratum radiatum nitroblue tetrazolium bovine serum albumin Fatty acid amide hydrolase stratum pyramidale immunoreactive Immunohistochemistry IGL lateral ventricle third ventricle Pir stria terminalis substantia nigra, pars compacta rostral migratory stream islands of Calleja periaqueductal gray optic tract Room temperature medial globus pallidus Subiculum Superior colliculus dentate gyrus Shi FMI lent Orbital cortex Retrosplenial cortex Agranular insular cortex Granular insular cortex primary auditory cortex lateral entorhinal cortex perirhinal cortex piriform cortex prelimbic cortex lateral olfactory tract Arc Stratum lacunosum-moleculare external plexiform layer of the olfactory bulb mitral cell layer of the olfactory bulb medial lemniscus Lot substantia innominata claustrum SUM Phosphate-buffered saline median eminence BMP subventricular zone lateral hypothalamic area anterior hypothalamic area ventral tegmental area Supramammillary nucleus Supraoptic nucleus anterior cortical amygdaloid nucleus anterior olfactory nucleus rhomboid thalamic nucleus reuniens thalamic nucleus lateral posterior thalamic nucleus reticular thalamic nucleus ventromedial thalamic nucleus paratenial thalamic nucleus bed nucleus of the stria terminalis Lateral mammillary nucleus Lateral habenular nucleus nucleus of the lateral olfactory tract lateral septal nucleus, dorsal part medial habenular nucleus posteromedial cortical amygdaloid nucleus nucleus of the horizontal limb of the diagonal band central amygdaloid nucleus medial amygdaloid nucleus Lateral amygdaloid nucleus dorsal lateral geniculate nucleus basolateral amygdaloid nucleus, anterior part dorsomedial hypothalamic nucleus arcuate hypothalamic nucleus paraventricular hypothalamic nucleus periventricular hypothalamic nucleus median preoptic nucleus medial geniculate nucleus ventral lateral geniculate nucleus dorsal endopiriform nucleus parafascicular thalamic nucleus anteroventral thalamic nucleus forebrain aci Cannabinoid anterior commissure cingulate cortex external capsule internal capsule Gro AON