Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro

Article ID	Journal	Published Year	Pages	File Type
6276046	Neuroscience	2011	10 Pages	PDF

Abstract

â¶mGluR5 promotes the proliferation of human embryonic neural progenitor cells. â¶mGluR5 increases cyclin D1 expression in human neural progenitor cells. â¶mGluR5 activates MAPKs pathways involving in self-renewing of neural progenitor cells.

Keywords

N-methyl-d-aspartic acid MPEP mGluR PKC Jnk EGF NMDA bFGF DHPG Cyclin D1 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide c-Jun N-terminal protein kinase DMEM/F12 ERKs MAPKs MTT NPCs Proliferation CNS neural stem/progenitor cells central nervous system epidermal growth factor basic fibroblast growth factor extracellular signal-regulated protein kinases Protein kinase C mitogen-activated protein kinases Metabotropic glutamate receptors