Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats

Article ID	Journal	Published Year	Pages	File Type
6276211	Neuroscience	2011	15 Pages	PDF

Abstract

â¶Pro-apoptotic Fas-FADD receptor complex is downregulated in brains of cocaine addicts. â¶Pro-apoptotic mitochondrial cytochrome c is reduced in brains of cocaine addicts. â¶Anti-apoptotic t-DARPP, truncated DARPP-32, is reduced in brains of cocaine addicts. â¶Nuclear PARP-1, a sensor of DNA damage, is increased in brains of cocaine addicts. â¶Chronic cocaine in rats only increased t-DARPP content in the cerebral cortex.154

Keywords

pKa FADD DISC CK1α DARPP-32 ECL DAT Postmortem delay Bcl-2 PEA-15 FAS PARP-1 Jnk SDS PAR-4 MAPK PMd Akt/PKB AIF Cocaine addiction Dopamine transporter Bax enhanced chemiluminescence Par sodium dodecyl sulfate Apoptotic signaling apoptosis-inducing factor phosphorylated Postmortem human brain Rat brain Bcl-2 Associated X protein Fas-associated protein with death domain protein kinase A mitogen-activated protein kinase Poly(ADP-ribose) polymerase-1 death-inducing signaling complex casein kinase 1α