Glutamatergic inputs and glutamate-releasing immature inhibitory inputs activate a shared postsynaptic receptor population in lateral superior olive

▶The mature lateral superior olive receives glutamatergic and glycinergic inputs. ▶The immature glycinergic inputs also release glutamate. ▶We asked whether these pathways could engage in glutamatergic crosstalk. ▶Glutamate spillover can activate NMDA receptors shared by both pathways. ▶Shared NMDA receptors may be proximal to classic glutamatergic synapses.