The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins

Article ID	Journal	Published Year	Pages	File Type
6276259	Neuroscience	2011	13 Pages	PDF

Abstract

â¶ER stress upregulates the KDEL receptor levels. â¶Overexpression of the KDEL receptor activates ERKs to induce autophagy. â¶The KDEL receptor mutants fail to induce autophagy. â¶The KDEL receptor promotes the clearance of neurodegenerative disease-related proteins.

Keywords

MEK1 α-Syn LC3 SOD1 Thapsigargin htt ATG5 autophagy-related gene 5 JNKs PBS ERGIC RFP KDEL Arf1 KDEL receptor c-Jun amino-terminal kinases Lys-Asp-Glu-Leu KDELR DAPI ERAD eGFP 4′,6-diamidino-2-phenylindole BiP ERKs MAPKs Alpha-synuclein Autophagy ER stress amyotrophic lateral sclerosis Tem ALS Huntington's disease Parkinson's disease ER-Associated Degradation CHOP superoxide dismutase 1 endoplasmic reticulum Phosphate buffered saline Transmission electron microscopy knockout wild-type Huntingtin Binding immunoglobulin Protein enhanced green fluorescence protein Red fluorescence protein microtubule-associated protein 1 light chain 3 extracellular signal-regulated kinases mitogen-activated protein kinases