Administration of the 5-HT2C receptor antagonist SB-242084 into the nucleus accumbens blocks the expression of ethanol-induced behavioral sensitization in Albino Swiss mice

▶Some mice treated 3 weeks with EtOH developed high sensitization to its stimulant effect. ▶Other mice under the same treatment (2.2 g/kg EtOH) developed weak sensitization. ▶SB-242084 intra-NAc reduced sensitization expression only in highly sensitized mice. ▶SB-242084 i.p. did not affect the expression of EtOH-induced sensitization. ▶Expression of behavioral sensitization to EtOH depends on accumbal 5-HT2CR activity.