| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6276410 | Neuroscience | 2011 | 14 Pages |
Abstract
â¶Addressing the novelty of therapeutic approach of multimodal iron chelating compounds. â¶Iron chelator M30 possesses various neuroprotective effects in mouse brain. â¶M30 activates HIF-1 signaling pathway and up-regulates specific HIF-target genes. â¶M30 up-regulates the expression of neurotrophic factors and antioxidant enzymes. â¶M30 induces pro-survival cell signaling cascades.
Keywords
HO-1GDNFGSK-3βHIF-1αGLUT-1PKCiNOSEPOTBSHeme oxygenase-1GPXdNTPDFOTFRPHDSOD-1M30DeferoxamineBDNFerythropoietinAlzheimer's diseaseTris buffered salinereverse transcriptioninducible nitric oxide synthaseSuperoxide dismutase-1Hypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Brain-derived neurotrophic factorglial cell-derived neurotrophic factorpolymerase chain reactionPCRProtein kinase CProlyl hydroxylaseIron chelationglutathione peroxidaseglucose transporter-1Glycogen synthase kinase-3βtransferrin receptor
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Authors
L. Kupershmidt, O. Weinreb, T. Amit, S. Mandel, O. Bar-Am, M.B.H. Youdim,