Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus

Article ID	Journal	Published Year	Pages	File Type
6276463	Neuroscience	2011	14 Pages	PDF

Abstract

â¶Long-term ginsenoside administration may prevent memory loss in aged C57BL/6J mice. â¶One of mechanisms is modulating the redox status in serum and in hippocampus. â¶The other mechanism is up-regulating the plasticity-related proteins in hippocampus. â¶This study can provide evidence for the prevention by ginsenoside on memory loss.

Keywords

T-SOD MWM PKC PKCγ GSH PSD-95 TBARS GSSG BDNF GSH-Px ROS Antioxidation Alzheimer's disease volume density postsynaptic density-95 Morris water maze test Memory total superoxide dismutase brain derived neurotrophic factor thiobarbituric acid reactive substances Hippocampus Protein kinase C Prevention Glutathione oxidized glutathione glutathione peroxidase Reactive oxygen species Ginsenoside